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Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

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Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

zhang2012.pdf

作者:Zhang, K (Zhang, Kang)[ 1,2,3,4,5 ] ; Zhang, LF (Zhang, Liangfang)[ 5,6 ] ; Weinreb, RN (Weinreb, Robert N.)[ 3,4 ]

NATURE REVIEWS DRUG DISCOVERY

: 11

 

: 7

 

: 541-559

DOI: 10.1038/nrd3745

出版年: JUL 2012

文献类型:Review

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摘要

Blindness affects 60 million people worldwide. The leading causes of irreversible blindness include age-related macular degeneration, retinal vascular diseases and glaucoma. The unique features of the eye provide both benefits and challenges for drug discovery and delivery. During the past decade, the landscape for ocular drug therapy has substantially changed and our knowledge of the pathogenesis of ophthalmic diseases has grown considerably. Anti-angiogenic drugs have emerged as the most effective form of therapy for age-related macular degeneration and retinal vascular diseases. Lowering intraocular pressure is still the mainstay for glaucoma treatment but neuroprotective drugs represent a promising next-generation therapy. This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities.

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